A collection of key publications from our immediate group and our collaborators worldwide.

Articles are separated into topics, which are indexed alphabetically by year.

 

Cerebral Autoregulation 

  • Costa CS, Placed MM, Czosnyka M, Cabella B, Kasprowicz M,  Austin T, Smielewski P. Complexity of brain signals is associated with outcome in preterm infants. JCBFM Jan 2017. 1:271678X16687314. doi: 10.1177/0271678X16687314. [Full Text Available]
  • Costa CS, Czosnyka M, Smielewski P, Mitra S, Stevenson GN, Austin T. Monitoring of cerebrovascular reactivity allows determination of optimal blood pressure in preterm infants. J Pediatr. 2015;167:86-91. https://doi.org/10.1016/j.jpeds.2015.03.041. [Full Text Available]
  • Budohoski KP, Czosnyka M, Smielewski P, Varsos GV, Kasprowicz M, Brady KM, et al. Cerebral Autoregulation after Subarachnoid Hemorrhage: Comparison of Three Methods. Journal of Cerebral Blood Flow & Metabolism. 2012 Dec 12;33(3):449–56http://doi.org/10.1038/jcbfm.2012.189 [Full Text Available]
  • Brady K, Joshi B, Zweifel C, Smielewski P, Czosnyka M, Easley RB, Hogue CW. Real-time continuous monitoring of cerebral blood flow autoregulation using near-infrared spectroscopy in patients undergoing cardiopulmonary bypass. Stroke. 2010 Sep 1;41(9):1951-6. [Full Text Available]
  • Czosnyka M, Brady K, Reinhard M, Smielewski P, Steiner LA. Monitoring of cerebrovascular autoregulation: facts, myths, and missing links. Neurocritical care. 2009 Jun 1;10(3):373-86. [Full Text Available]
  • Czosnyka M, Balestreri M, Steiner L, Smielewski P, Hutchinson PJ, Matta B, Pickard JD. Age, intracranial pressure, autoregulation, and outcome after brain trauma. Journal of neurosurgery. 2005 Mar;102(3):450-4. [Full Text Available]
  • Steiner LA, Coles JP, Johnston AJ, Chatfield DA, Smielewski P, Fryer TD, Aigbirhio FI, Clark JC, Pickard JD, Menon DK, Czosnyka M. Assessment of cerebrovascular autoregulation in head-injured patients. Stroke. 2003 Oct 1;34(10):2404-9. [Full Text Available]
  • Czosnyka M, Smielewski P, Piechnik S, Steiner LA, Pickard JD. Cerebral autoregulation following head injury. Journal of neurosurgery. 2001 Nov;95(5):756-63. [Full Text Available]
  • Czosnyka M, Smielewski P, Kirkpatrick P, Menon DK, Pickard JD. Monitoring of cerebral autoregulation in head-injured patients. Stroke. 1996 Oct 1;27(10):1829-34. [Full Text Available]

 

Cerebrospinal Fluid Dynamics

  • Czosnyka M, Czosnyka Z, Momjian S, Pickard JD. Cerebrospinal fluid dynamics. Physiological measurement. 2004 Aug 6;25(5):R51. [Full Text Available]
  • Czosnyka M, Smielewski P, Kirkpatrick P, Laing RJ, Menon D, Pickard JD. Continuous Assessment of the Cerebral Vasomotor Reactivity in Head Injury. Neurosurgery. 1997;41(1):11–9. [Full Text Available]
  • Czosnyka M, Whitehouse H, Smielewski P, Simac S, Pickard JD. Testing of cerebrospinal compensatory reserve in shunted and non-shunted patients: a guide to interpretation based on an observational study. Journal of Neurology, Neurosurgery & Psychiatry. 1996 May 1;60(5):549-58. [Full Text Available]
  • Børgesen SE, Albeck MJ, Gjerris F, Czosnyka M, Laniewski P. Computerized infusion test compared to steady pressure constant infusion test in measurement of resistance to CSF outflow. Acta neurochirurgica. 1992 Mar 1;119(1-4):12-6. [Full Text Available]
  • Avezaat CJ, Eijndhoven JHV, Wyper DJ. Cerebrospinal fluid pulse pressure and intracranial volume-pressure relationships. Journal of Neurology, Neurosurgery & Psychiatry. 1979Jan;42(8):687–700. [Full Text Available]
  • Marmarou A, Shulman K, Rosende RM. A nonlinear analysis of the cerebrospinal fluid system and intracranial pressure dynamics. Journal of Neurosurgery. 1978;48(3):332–44. [Full Text Available]

 

Cerebral Perfusion Pressure and Optimal Cerebral Perfusion Pressure 

  • Dias C, Silva MJ, Pereira E, Monteiro E, Maia I, Barbosa S, Silva S, Honrado T, Cerejo A, Aries MJ, Smielewski P. Optimal cerebral perfusion pressure management at bedside: a single-center pilot study. Neurocritical care. 2015 Aug 1;23(1):92-102. [Full Text Available]
  • Aries MJ, Czosnyka M, Budohoski KP, Steiner LA, Lavinio A, Kolias AG, Hutchinson PJ, Brady KM, Menon DK, Pickard JD, Smielewski P. Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury. Critical care medicine. 2012 Aug 1;40(8):2456-63.[Full Text Available]
  • Steiner LA, Czosnyka M, Piechnik SK, Smielewski P, Chatfield D, Menon DK, Pickard JD. Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic brain injury. Critical care medicine. 2002 Apr 1;30(4):733-8. [Full Text Available]
  • Czosnyka M, Matta BF, Smielewski P, Kirkpatrick PJ, Pickard JD. Cerebral perfusion pressure in head-injured patients: a noninvasive assessment using transcranial Doppler ultrasonography. Journal of neurosurgery. 1998 May;88(5):802-8. [Full Text Available]

 

Hydrocephalus 

  • Momjian S, Owler BK, Czosnyka Z, Czosnyka M, Pena A, Pickard JD. Pattern of white matter regional cerebral blood flow and autoregulation in normal pressure hydrocephalus. Brain. 2004 May 1;127(5):965-72. [Full Text Available]
  • Owler BK, Momjian S, Czosnyka Z, Czosnyka M, Péna A, Harris NG, Smielewski P, Fryer T, Donovan T, Coles J, Carpenter A. Normal pressure hydrocephalus and cerebral blood flow: a PET study of baseline values. Journal of Cerebral Blood Flow & Metabolism. 2004 Jan;24(1):17-23. [Full Text Available]
  • Czosnyka M, Czosnyka ZH, Whitfield PC, Donovan T, Pickard JD. Age dependence of cerebrospinal pressure—volume compensation in patients with hydrocephalus. Journal of neurosurgery. 2001 Mar;94(3):482-6. [Full Text Available]
  • Iddon JL, Pickard JD, Cross JJ, Griffiths PD, Czosnyka M, Sahakian BJ. Specific patterns of cognitive impairment in patients with idiopathic normal pressure hydrocephalus and Alzheimer9s disease: a pilot study. Journal of Neurology, Neurosurgery & Psychiatry. 1999 Dec 1;67(6):723-32. [Full Text Available]
  • Czosnyka Z, Czosnyka M, Richards HK, Pickard JD. Posture-related overdrainage: comparison of the performance of 10 hydrocephalus shunts in vitro. Neurosurgery. 1998 Feb 1;42(2):327-34. [Full Text Available]

 

ICM+ Software and Bedside Monitoring 

  • Smielewski P, Czosnyka Z, Kasprowicz M, Pickard JD, Czosnyka M. ICM+: a versatile software for assessment of CSF dynamics. InIntracranial Pressure and Brain Monitoring XIV 2012 (pp. 75-79). Springer Vienna. [Full Text Available]
  • Smielewski P, Lavinio A, Timofeev I, Radolovich D, Perkes I, Pickard JD,Czosnyka M. ICM+, a flexible platform for investigations of cerebrospinal dynamics in clinical practice. Acta Neurochir Suppl. 2008;102:145-51. [Full Text Available]
  • Guendling K, Smielewski P, Czosnyka M, Lewis P, Nortje J, Timofeev I, Hutchinson PJ, Pickard JD. Use of ICM+ software for on-line analysis of intracranial and arterial pressures in head-injured patients. InBrain edema XIII 2006 (pp. 108-113). Springer Vienna. [Full Text Available]
  • Smielewski P, Czosnyka M, Steiner L, Belestri M, Piechnik S, Pickard JD. ICM+: software for on-line analysis of bedside monitoring data after severe head trauma. InIntracranial pressure and brain monitoring XII 2005 (pp. 43-49). Springer Vienna. [Full Text Available]

 

Intracranial Pressure 

  • Lewis PM, Smielewski P, Rosenfeld JV, Pickard JD, Czosnyka M. Monitoring of the association between cerebral blood flow velocity and intracranial pressure. In Intracranial Pressure and Brain Monitoring XIV 2012 (pp. 147-151). Springer Vienna. [Full Text Available]
  • Castellani G, Zweifel C, Kim DJ, Carrera E, Radolovich DK, Smielewski P, Hutchinson PJ, Pickard JD, Czosnyka M. Plateau waves in head injured patients requiring neurocritical care. Neurocritical care. 2009 Oct 1;11(2):143-50. [Full Text Available]
  • Timofeev I, Czosnyka M, Nortje J, Smielewski P, Kirkpatrick P, Gupta A, Hutchinson P. Effect of decompressive craniectomy on intracranial pressure and cerebrospinal compensation following traumatic brain injury. [Full Text Available]
  • Balestreri M, Czosnyka M, Hutchinson P, Steiner LA, Hiler M, Smielewski P, Pickard JD. Impact of intracranial pressure and cerebral perfusion pressure on severe disability and mortality after head injury. Neurocritical care. 2006 Feb 1;4(1):8-13. [Full Text Available]
  • Czosnyka M, Pickard JD. Monitoring and interpretation of intracranial pressure. Journal of Neurology, Neurosurgery & Psychiatry. 2004 Jun 1;75(6):813-21. [Full Text Available]

 

Non-invasive Intracranial Pressure 

  • Cardim D, Schmidt B, Robba C, Donnelly J, Puppo C, Czosnyka M, and Smielewski P. Transcranial Doppler Monitoring of Intracranial Pressure Plateau Waves. Neurocrit. Care. 2017; 26(3): 330–338. [Full Text Available]
  • Cardim D, Robba C, Bohdanowicz M, Donnelly J, Cabella B, Liu X, Cabeleira M, et al. Non-invasive Monitoring of Intracranial Pressure Using Transcranial Doppler Ultrasonography: Is It Possible? Neurocrit. Care. 2016; 25(3):473–491. [Full Text Available]
  • Cardim D, Czosnyka M, Donnelly J, Robba C, Cabella BCT, Liu X, et al. Assessment of non-invasive ICP during CSF infusion test: an approach with transcranial Doppler. Acta Neurochirurgica 2015;158:279–87. doi:10.1007/s00701-015-2661-8. [Full Text Available]
  • Cardim D, Robba C, Donnelly J, Bohdanowicz M, Schmidt B, Damian M, Varsos GV, et al. Prospective study on non-invasive assessment of ICP in head injured patients: comparison of four methods. J. Neurotrauma. 2015 Sep; 33: 1-11. doi: 10.1089/neu.2015.4134. [Full Text Available]
  • Robba C, Donnelly J, Bertuetti R, Cardim D, Sekhon MS, Aries M, et al. Doppler Non-invasive Monitoring of ICP in an Animal Model of Acute Intracranial Hypertension. Neurocritical Care 2015;23:419–26. doi:10.1007/s12028-015-0163-4. [Full Text Available]
  • Varsos GV, Kolias AG, Smielewski P, Brady KM, Varsos VG, Hutchinson PJ, Pickard JD, and Czosnyka M. A noninvasive estimation of cerebral perfusion pressure using critical closing pressure. J. Neurosurg. 2015; 123(3): 638-648. [Full Text Available]
  • Schmidt B, Czosnyka M, and Klingelhöfer J. Clinical applications of a non-invasive ICP monitoring method. Eur. J. Ultrasound. 2002;16,37–45. [Full Text Available]
  • Schmidt B, Klingelhöfer J, Schwarze JJ, Sander D, Wittich I. Noninvasive prediction of intracranial pressure curves using transcranial Doppler ultrasonography and blood pressure curves. Stroke. 1997;  [Full Text Available]
  • Schmidt B, Czosnyka M, Smielewski P, Plontke R, Schwarze JJ, Klingelhöfer J, Pickard JD. Noninvasive Assessment of ICP: Evaluation of New TBI Data. In Intracranial Pressure and Brain Monitoring XV 2016 (pp. 69-73). Springer International Publishing. [Full Text Available]
  • Schmidt B, Czosnyka M, Raabe A, Yahya H, Schwarze JJ, Sackerer D, Sander D, Klingelhöfer J. Adaptive noninvasive assessment of intracranial pressure and cerebral autoregulation. Stroke. 2003 Jan 1;34(1):84-9. [Full Text Available]
  • Czosnyka M, Matta BF, Smielewski P, Kirkpatrick PJ, Pickard JD. Cerebral perfusion pressure in head-injured patients: a noninvasive assessment using transcranial Doppler ultrasonography. Journal of Neurosurgery 1998;88:802–8. doi:10.3171/jns.1998.88.5.0802. [Full Text Available]

 

Pressure Reactivity Index 

  • Budohoski KP, Czosnyka M, de Riva N, Smielewski P, Pickard JD, Menon DK, Kirkpatrick PJ, Lavinio A. The relationship between cerebral blood flow autoregulation and cerebrovascular pressure reactivity after traumatic brain injury. Neurosurgery. 2012 May 30;71(3):652-61. [Full Text Available]
  • Zweifel C, Lavinio A, Steiner LA, Radolovich D, Smielewski P, Timofeev I, Hiler M, Balestreri M, Kirkpatrick PJ, Pickard JD, Hutchinson P. Continuous monitoring of cerebrovascular pressure reactivity in patients with head injury. Neurosurgical focus. 2008 Oct;25(4):E2. [Full Text Available]
  • Steiner LA, Coles JP, Czosnyka M, Minhas PS, Fryer TD, Aigbirhio FI, Clark JC, Smielewski P, Chatfield DA, Donovan T, Pickard JD. Cerebrovascular pressure reactivity is related to global cerebral oxygen metabolism after head injury. Journal of Neurology, Neurosurgery & Psychiatry. 2003 Jun 1;74(6):765-70. [Full Text Available]
  • Steiner LA, Czosnyka M, Piechnik SK, Smielewski P, Chatfield D, Menon DK, Pickard JD. Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic brain injury. Critical care medicine. 2002 Apr 1;30(4):733-8. [Full Text Available]
  • Czosnyka M, Smielewski P, Kirkpatrick P, Laing RJ, Menon D, Pickard JD. Continuous assessment of the cerebral vasomotor reactivity in head injury. Neurosurgery. 1997 Jul 1;41(1):11-9. [Full Text Available]

 

Subarachnoid Hemorrhage 

  • Budohoski KP, Czosnyka M, Kirkpatrick PJ, Reinhard M, Varsos GV, Kasprowicz M, Ząbek M, Pickard JD, Smielewski P. Bilateral failure of cerebral autoregulation is related to unfavorable outcome after subarachnoid hemorrhage. Neurocritical care. 2015 Feb 1;22(1):65-73. [Full Text Available]
  • Tseng MY, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ. Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage. Stroke. 2005 Aug 1;36(8):1627-32. [Full Text Available]
  • Soehle M, Czosnyka M, Pickard JD, Kirkpatrick PJ. Continuous assessment of cerebral autoregulation in subarachnoid hemorrhage. Anesthesia & Analgesia. 2004 Apr 1;98(4):1133-9. [Full Text Available]
  • Minhas PS, Menon DK, Smielewski P, Czosnyka M, Kirkpatrick PJ, Clark JC, Pickard JD. Positron emission tomographic cerebral perfusion disturbances and transcranial Doppler findings among patients with neurological deterioration after subarachnoid hemorrhage. Neurosurgery. 2003 May 1;52(5):1017-24. [Full Text Available]

 

Transcranial Doppler Ultrasonography 

  • de Riva N, Budohoski KP, Smielewski P, Kasprowicz M, Zweifel C, Steiner LA, Reinhard M, Fábregas N, Pickard JD, Czosnyka M. Transcranial Doppler pulsatility index: what it is and what it isn’t. Neurocritical care. 2012 Aug 1;17(1):58-66. [Full Text Available]
  • Sorrentino E, Budohoski KP, Kasprowicz M, Smielewski P, Matta B, Pickard JD, Czosnyka M. Critical thresholds for transcranial Doppler indices of cerebral autoregulation in traumatic brain injury. Neurocritical care. 2011 Apr 1;14(2):188-93. [Full Text Available]
  • Soehle M, Chatfield DA, Czosnyka M, Kirkpatrick PJ. Predictive value of initial clinical status, intracranial pressure and transcranial Doppler pulsatility after subarachnoid haemorrhage. Acta neurochirurgica. 2007 Jun 1;149(6):575-83. [Full Text Available]
  • Schmidt EA, Czosnyka M, Gooskens I, Piechnik SK, Matta BF, Whitfield PC, Pickard JD. Preliminary experience of the estimation of cerebral perfusion pressure using transcranial Doppler ultrasonography. Journal of Neurology, Neurosurgery & Psychiatry. 2001 Feb 1;70(2):198-204. [Full Text Available]
  • Czosnyka M, Richards HK, Whitehouse HE, Pickard JD. Relationship between transcranial Doppler-determined pulsatility index and cerebrovascular resistance: an experimental study. Journal of neurosurgery. 1996 Jan;84(1):79-84. [Full Text Available]
  • Aaslid R, Huber P, Nornes H. Evaluation of cerebrovascular spasm with transcranial Doppler ultrasound. Journal of neurosurgery. 1984 Jan;60(1):37-41. [Full Text Available]
  • Aaslid R, Markwalder TM, Nornes H. Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. Journal of neurosurgery. 1982 Dec;57(6):769-74. [Full Text Available]
  • Varsos, G. V., Kasprowicz, M., Smielewski, P., & Czosnyka, M. (2014). Model-based indices describing cerebrovascular dynamics. Neurocritical Care, 20(1), 142–157. http://doi.org/10.1007/s12028-013-9868-4. [Full Text Available]
  • Varsos, G. V., Richards, H., Kasprowicz, M., Budohoski, K. P., Brady, K. M., Reinhard, M., … Czosnyka, M. (2013). Critical closing pressure determined with a model of cerebrovascular impedance. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 33(2), 235–43. http://doi.org/10.1038/jcbfm.2012.161. [Full Text Available]

 

Experimental research

Donnelly J, Czosnyka M, Harland S, Varsos GV, Cardim D, Robba C, Liu X, Ainslie PN, Smielewski P, Cerebral haemodynamics during experimental intracranial hypertension. 2017 Feb;37(2):694-705.  [Full Text Available]

Robba C, Donnelly J2, Bertuetti R3, Cardim D2, Sekhon MS4, Aries M2, Smielewski P2, Richards H2, Czosnyka M2, Doppler Non-invasive Monitoring of ICP in an Animal Model of Acute Intracranial Hypertension, 2015 Dec;23(3):419-26. [Full Text Available]

Varsos GV, Richards H, Kasprowicz M, Budohoski KP, Brady KM, Reinhard M, Avolio A, Smielewski P, Pickard JD, Czosnyka M, Critical closing pressure determined with a model of cerebrovascular impedance, 2013 Feb;33(2):235-43. [Full Text Available]

Varsos GV, Richards HK, Kasprowicz M, Reinhard M, Smielewski P, Brady KM, Pickard JD, Czosnyka M, Cessation of diastolic cerebral blood flow velocity: the role of critical closing pressure, 2014 Feb;20(1):40-8. [Full Text Available]