Cerebrospinal fluid circulation : from the patient to ICM+ and back

Why study hydrocephalus?
Relatively infrequent condition but the only reversible dementia so far!
Modelling CSF dynamics contributes to:

  • Increasing diagnostic accuracy
  • Researching and further understanding the underlying disease mechanisms
  • Predicting the effectiveness of neurosurgical intervention
  • Diagnosing problems with shunts

In both shunted and non-shunted patients:
– Short – term ICP monitoring is achieved with infusion studies
– Long – term (Overnight) ICP monitoring

Idiopathic Intracranial Hypertension is also a rare disease that remains poorly understood in both the adult but especially the paediatric population.

CSF dynamics of IIH are completely different from hydrocephalic individuals and investigating these patients in conjunction with the clinical and imaging interventions allows us to trace disturbances in many patients with complicated courses requiring interdisciplinary care

Infusion study - non-shunted IIH patient
Baseline ICP is >20 mmHg, with relatively low plteau and sunsequently low Resistance to CSF outflow. Disturbance of CSF dynamics is therefore underlined by different parametres calculated in the ICM+ infusion test

Shunt testing in vivo: the importance & impact of the computerised CSF infusion test


CSF infusion tests in shunted individuals are critical in preventing unnecessary, blind revisions of shunts & provide evidence of shunt malfunction.

THe CSF infusion test for shunt testing in vivo was developed after years of experience in the Cambridge shunt testing laboratory;

all the shunt properties and the analysis of the CSF dynamics after shunting for testing of the shunt function are integrated in ICM+